Hematological Profile of Iron Overload in Rats Administered with Fruit Extract of Mahkota Dewa (Phaleria macrocarpa)

Background: Repeated blood transfusions lead to an accumulation of iron that exceeds the body's storage capacity. Free is able catalyze formation hydroxyl radicals cause oxidative damage and cell death. The use chelating medicines for chelation therapy limited by side effects. Mangiferin a natural bioactive compound with antioxidant activity. Mahkota dewa plant native Indonesia contains mangiferin. Objectives: aim this study was evaluate effect mahkota fruit extract administration on hematological profile overload rats. Material Methods: Thirty rats were divided into 6 groups: normal (N), (IO), given deferiprone (D), mangiferin (M), at dose 100 mg/kg BW (PM1), or 200 (PM2). Rats injection sucrose 15 mg every 3-4 days 8 weeks. At week 8, sacrificed. Hematological analysis performed in study. Results: Iron condition caused did not statistically significant changes haematological profile. Likewise, Conclusions: alter oveload